At this time, there are two styles of scientific tests on itaconate: Irg1−/− macrophages along with the regulatory impact of itaconate derivatives. These two outcomes were being complementary and revealed the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription component three (ATF3) https://bendamustine66532.dbblog.net/3016984/the-smart-trick-of-ncoa4-9a-that-nobody-is-discussing