Central administration of palmitoylethanolamide lowers hyperalgesia in mice by means of inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J Pharmacol Costa and colleagues [178] have proposed that PEA was in a position to cut back mechanical allodynia and thermal hyperalgesia following sciatic nerve constriction in mice, https://dantesneui.ttblogs.com/10007593/getting-my-palmitoylethanolamide-to-work