Amplified activation of essential oncogenic signalling pathways (PI3K/AKT, RAS/MAPK and MYC) upstream of ribosome biogenesis constitutes an extra hallmark of HGSC,9 and we hypothesise that inhibiting ribosome biogenesis can offer a successful cancer therapeutic option.10 In fact, We've demonstrated encouraging responses Using the ribosomal RNA gene (rDNA) transcription inhibitor CX-5461, https://miltong297xcg0.wikifordummies.com/user