Pentobarbital will decrease the level or effect of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of atogepant by affecting hepatic/intestinal enzy... https://getsocialsource.com/story5738053/5-fatti-facile-circa-pentobarbital-natrium-descritto